6R5H
Major aspartyl peptidase 1 from C. neoformans
Summary for 6R5H
Entry DOI | 10.2210/pdb6r5h/pdb |
Descriptor | Endopeptidase, PENTAETHYLENE GLYCOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | aspartyl protease, secreted, cryptococcus neoformans, hydrolase |
Biological source | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) |
Total number of polymer chains | 1 |
Total formula weight | 39113.55 |
Authors | Krystufek, R.,Sacha, P.,Brynda, J.,Konvalinka, J. (deposition date: 2019-03-25, release date: 2021-04-07, Last modification date: 2021-06-09) |
Primary citation | Krystufek, R.,Sacha, P.,Starkova, J.,Brynda, J.,Hradilek, M.,Tloust'ova, E.,Grzymska, J.,Rut, W.,Boucher, M.J.,Drag, M.,Majer, P.,Hajek, M.,Rezacova, P.,Madhani, H.D.,Craik, C.S.,Konvalinka, J. Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. J.Med.Chem., 64:6706-6719, 2021 Cited by PubMed: 34006103DOI: 10.1021/acs.jmedchem.0c02177 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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