6R4E

Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu

6R4E の概要

• エントリーDOI: 10.2210/pdb6r4e/pdb
• 分子名称: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, ... (4 entities in total)
• 機能のキーワード: glutamine fructose-6-phosphate aminotransferase, gfat, ntn hydrolase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 156219.37

構造登録者

Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. (登録日: 2019-03-22, 公開日: 2020-01-15, 最終更新日: 2024-01-24)

• 主引用文献: Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S.; Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.; Nat Commun, 11:687-687, 2020; PubMed: 32019926; DOI: 10.1038/s41467-020-14524-5

実験手法

X-RAY DIFFRACTION (2.353 Å)