6R1K

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7c

6R1K の概要

• エントリーDOI: 10.2210/pdb6r1k/pdb
• 分子名称: Cereblon isoform 4, ZINC ION, ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-2,4,6-tris(chloranyl)benzamide, ... (5 entities in total)
• 機能のキーワード: proteolysis targeting chimera, protac, protein degradation, signaling protein
• 由来する生物種: Magnetospirillum gryphiswaldense MSR-1
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42688.10

構造登録者

Heim, C.,Hartmann, M.D. (登録日: 2019-03-14, 公開日: 2019-08-07, 最終更新日: 2024-01-24)

• 主引用文献: Heim, C.,Pliatsika, D.,Mousavizadeh, F.,Bar, K.,Hernandez Alvarez, B.,Giannis, A.,Hartmann, M.D.; De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.; J.Med.Chem., 62:6615-6629, 2019; PubMed: 31251063; DOI: 10.1021/acs.jmedchem.9b00454

実験手法

X-RAY DIFFRACTION (1.94 Å)