6R0K

X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS208

6R0K の概要

• エントリーDOI: 10.2210/pdb6r0k/pdb
• 分子名称: Histone deacetylase 6, ZINC ION, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: protein deacetylase, histone deacetylase 6, zinc-binding, isoxazole-3-hydroxamate analogues, hydrolase
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40851.54

構造登録者

Barinka, C.,Ustinova, K.,Motlova, L.,Pavlicek, J. (登録日: 2019-03-13, 公開日: 2019-10-09, 最終更新日: 2024-01-24)

• 主引用文献: Shen, S.,Hadley, M.,Ustinova, K.,Pavlicek, J.,Knox, T.,Noonepalle, S.,Tavares, M.T.,Zimprich, C.A.,Zhang, G.,Robers, M.B.,Barinka, C.,Kozikowski, A.P.,Villagra, A.; Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.; J.Med.Chem., 62:8557-8577, 2019; PubMed: 31414801; DOI: 10.1021/acs.jmedchem.9b00946

実験手法

X-RAY DIFFRACTION (1.15 Å)