6QXZ

Solution structure of the ASHH2 CW domain with the N-terminal histone H3 tail mimicking peptide monomethylated on lysine 4

Replaces:  6HBO

Summary for 6QXZ

• Entry DOI: 10.2210/pdb6qxz/pdb
• NMR Information: BMRB: 27251
• Descriptor: Histone-lysine N-methyltransferase ASHH2, ALA-ARG-THR-MLZ-GLN-THR-ALA-ARG-TYR, ZINC ION (3 entities in total)
• Functional Keywords: the cw domain of the methyltransferase from arabidopsis (ashh2). ashh2 binds mono- di- and tri-methylated on k4 n-terminal histone tail h3 via cw domain., plant protein, transferase
• Biological source: Arabidopsis thaliana (thale cress); More
• Total number of polymer chains: 2
• Total formula weight: 10067.35

Authors

Dobrovolska, O.,Madeleine, N.,Teigen, K.,Halskau, O.,Bril'kov, M. (deposition date: 2019-03-08, release date: 2019-12-04, Last modification date: 2023-06-14)

• Primary citation: Dobrovolska, O.,Brilkov, M.,Madeleine, N.,Odegard-Fougner, O.,Stromland, O.,Martin, S.R.,De Marco, V.,Christodoulou, E.,Teigen, K.,Isaksson, J.,Underhaug, J.,Reuter, N.,Aalen, R.B.,Aasland, R.,Halskau, O.; The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection.; Febs J., 287:4458-4480, 2020; PubMed: 32083791; DOI: 10.1111/febs.15256

Experimental method

SOLUTION NMR