6QXH
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP
Summary for 6QXH
| Entry DOI | 10.2210/pdb6qxh/pdb |
| Related | 6QXG |
| Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
| Functional Keywords | human thymidylate synthase, folate pathway, substrate, dump, transferase |
| Biological source | Homo sapiens |
| Total number of polymer chains | 3 |
| Total formula weight | 112805.82 |
| Authors | Pozzi, C.,Mangani, M. (deposition date: 2019-03-07, release date: 2019-04-10, Last modification date: 2024-01-24) |
| Primary citation | Pozzi, C.,Ferrari, S.,Luciani, R.,Tassone, G.,Costi, M.P.,Mangani, S. Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities. Molecules, 24:-, 2019 Cited by PubMed: 30935102DOI: 10.3390/molecules24071257 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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