6QXH

Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP

6QXH の概要

• エントリーDOI: 10.2210/pdb6qxh/pdb
• 関連するPDBエントリー: 6QXG
• 分子名称: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• 機能のキーワード: human thymidylate synthase, folate pathway, substrate, dump, transferase
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 112805.82

構造登録者

Pozzi, C.,Mangani, M. (登録日: 2019-03-07, 公開日: 2019-04-10, 最終更新日: 2024-01-24)

• 主引用文献: Pozzi, C.,Ferrari, S.,Luciani, R.,Tassone, G.,Costi, M.P.,Mangani, S.; Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.; Molecules, 24:-, 2019; PubMed: 30935102; DOI: 10.3390/molecules24071257

実験手法

X-RAY DIFFRACTION (2.04 Å)