6QXG
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with FdUMP
Summary for 6QXG
Entry DOI | 10.2210/pdb6qxg/pdb |
Descriptor | Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | human thymidylate synthase, folate pathway, inhibitor, fdump, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 112579.94 |
Authors | Pozzi, C.,Mangani, M. (deposition date: 2019-03-07, release date: 2019-04-10, Last modification date: 2024-01-24) |
Primary citation | Pozzi, C.,Ferrari, S.,Luciani, R.,Tassone, G.,Costi, M.P.,Mangani, S. Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities. Molecules, 24:-, 2019 Cited by PubMed: 30935102DOI: 10.3390/molecules24071257 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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