6QXD

Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site.

Summary for 6QXD

Entry DOI	10.2210/pdb6qxd/pdb
Descriptor	Tyrosinase, COPPER (II) ION, (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, ... (4 entities in total)
Functional Keywords	tyrosinase, inhibitor, ligand, oxidoreductase
Biological source	Bacillus megaterium
Total number of polymer chains	2
Total formula weight	67221.07
Authors	Deri Zenaty, B.,Gitto, R.,Pazy, Y.,Fishman, A. (deposition date: 2019-03-07, release date: 2019-06-19, Last modification date: 2024-01-24)
Primary citation	Ielo, L.,Deri, B.,Germano, M.P.,Vittorio, S.,Mirabile, S.,Gitto, R.,Rapisarda, A.,Ronsisvalle, S.,Floris, S.,Pazy, Y.,Fais, A.,Fishman, A.,De Luca, L. Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur.J.Med.Chem., 178:380-389, 2019 Cited by PubMed: 31202126 DOI: 10.1016/j.ejmech.2019.06.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.317 Å)

Structure validation