6QXD

Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site.

6QXD の概要

• エントリーDOI: 10.2210/pdb6qxd/pdb
• 分子名称: Tyrosinase, COPPER (II) ION, (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, ... (4 entities in total)
• 機能のキーワード: tyrosinase, inhibitor, ligand, oxidoreductase
• 由来する生物種: Bacillus megaterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67221.07

構造登録者

Deri Zenaty, B.,Gitto, R.,Pazy, Y.,Fishman, A. (登録日: 2019-03-07, 公開日: 2019-06-19, 最終更新日: 2024-01-24)

• 主引用文献: Ielo, L.,Deri, B.,Germano, M.P.,Vittorio, S.,Mirabile, S.,Gitto, R.,Rapisarda, A.,Ronsisvalle, S.,Floris, S.,Pazy, Y.,Fais, A.,Fishman, A.,De Luca, L.; Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.; Eur.J.Med.Chem., 178:380-389, 2019; PubMed: 31202126; DOI: 10.1016/j.ejmech.2019.06.019

実験手法

X-RAY DIFFRACTION (2.317 Å)