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6QX2

3.4A structure of benzoisoxazole 3 with S.aureus DNA gyrase and DNA

Summary for 6QX2
Entry DOI10.2210/pdb6qx2/pdb
Related6QX1
DescriptorDNA gyrase subunit B,DNA gyrase subunit B, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*T)-3'), (2~{R})-2-[[5-(2-chlorophenyl)-1,2-benzoxazol-3-yl]oxy]-2-phenyl-ethanamine, ... (13 entities in total)
Functional Keywordsinhibitor, dna complex, isomerase
Biological sourceStaphylococcus aureus
More
Total number of polymer chains36
Total formula weight993375.08
Authors
Bax, B.D. (deposition date: 2019-03-06, release date: 2019-04-17, Last modification date: 2024-01-24)
Primary citationThalji, R.K.,Raha, K.,Andreotti, D.,Checchia, A.,Cui, H.,Meneghelli, G.,Profeta, R.,Tonelli, F.,Tommasi, S.,Bakshi, T.,Donovan, B.T.,Howells, A.,Jain, S.,Nixon, C.,Quinque, G.,McCloskey, L.,Bax, B.D.,Neu, M.,Chan, P.F.,Stavenger, R.A.
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Bioorg.Med.Chem.Lett., 29:1407-1412, 2019
Cited by
PubMed: 30962087
DOI: 10.1016/j.bmcl.2019.03.029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.4 Å)
Structure validation

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