6QUV

Crystal Structure of KRAS-G12D in complex with GMP-PCP and compound 15R

Summary for 6QUV

• Entry DOI: 10.2210/pdb6quv/pdb
• Descriptor: GTPase KRas, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: ppi, kras, gtpase, cancer, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40212.18

Authors

Fischer, G.,Kessler, D.,Muellauer, B.,Wolkerstorfer, B. (deposition date: 2019-02-28, release date: 2019-07-31, Last modification date: 2024-05-15)

• Primary citation: Bergner, A.,Cockcroft, X.,Fischer, G.,Gollner, A.,Hela, W.,Kousek, R.,Mantoulidis, A.,Martin, L.J.,Mayer, M.,Mullauer, B.,Siszler, G.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B.; KRAS Binders Hidden in Nature.; Chemistry, 25:12037-12041, 2019; PubMed: 31231840; DOI: 10.1002/chem.201902810

Experimental method

X-RAY DIFFRACTION (1.475 Å)