6QTN

Tubulin-cyclostreptin complex

6QTN の概要

• エントリーDOI: 10.2210/pdb6qtn/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cyclostreptin, ... (14 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265671.68

構造登録者

Balaguer, F.d.A.,Muehlethaler, T.,Estevez-Gallego, J.,Calvo, E.,Gimenez-Abian, J.F.,Risinger, A.L.,Sorensen, E.J.,Vanderwal, C.D.,Altmann, K.-H.,Mooberry, S.L.,Steinmetz, M.O.,Oliva, M.A.,Prota, A.E.,Diaz, J.F. (登録日: 2019-02-25, 公開日: 2019-04-03, 最終更新日: 2024-01-24)

• 主引用文献: Balaguer, F.A.,Muhlethaler, T.,Estevez-Gallego, J.,Calvo, E.,Gimenez-Abian, J.F.,Risinger, A.L.,Sorensen, E.J.,Vanderwal, C.D.,Altmann, K.H.,Mooberry, S.L.,Steinmetz, M.O.,Oliva, M.A.,Prota, A.E.,Diaz, J.F.; Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.; Int J Mol Sci, 20:-, 2019; PubMed: 30897704; DOI: 10.3390/ijms20061392

実験手法

X-RAY DIFFRACTION (1.9 Å)