6QS0

NMR structure of BB_A03, Borrelia burgdorferi outer surface lipoprotein

6QS0 の概要

• エントリーDOI: 10.2210/pdb6qs0/pdb
• NMR情報: BMRB: 34361
• 分子名称: Putative outer membrane protein BBA03 (1 entity in total)
• 機能のキーワード: lipoprotein, membrane protein
• 由来する生物種: Borreliella burgdorferi B31
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13746.59

構造登録者

Fridmanis, J.,Brangulis, K.,Jaudzems, K. (登録日: 2019-02-20, 公開日: 2020-03-18, 最終更新日: 2024-06-19)

主引用文献

Fridmanis, J.,Bobrovs, R.,Brangulis, K.,Tars, K.,Jaudzems, K.
Structural and Functional Analysis of BBA03, Borrelia burgdorferi Competitive Advantage Promoting Outer Surface Lipoprotein.
Pathogens, 9:-, 2020

PubMed Abstract: BBA03 is a outer surface lipoprotein encoded on one of the most conserved plasmids in genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic and evolutionary relatedness. Analysis of the structure reveals a pore in BBA03, which could potentially bind lipids.

PubMed: 33050189
DOI: 10.3390/pathogens9100826

実験手法

SOLUTION NMR