6QOX
Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 27 (Methyl 2-(hydroxymethyl)-6H-thieno[2,3-b]pyrrole-5-carboxylate)
Summary for 6QOX
Entry DOI | 10.2210/pdb6qox/pdb |
Related | 6NVR |
Descriptor | tRNA (guanine-N(1)-)-methyltransferase, methyl 2-(hydroxymethyl)-6~{H}-thieno[2,3-b]pyrrole-5-carboxylate (3 entities in total) |
Functional Keywords | trmd, trna methyltransferase, spout methyltransferase, transferase |
Biological source | Mycobacterium abscessus |
Total number of polymer chains | 2 |
Total formula weight | 53080.58 |
Authors | Thomas, S.E.,Whitehouse, A.J.,Coyne, A.G.,Abell, C.,Mendes, V.,Blundell, T.L. (deposition date: 2019-02-12, release date: 2020-02-26, Last modification date: 2024-05-15) |
Primary citation | Thomas, S.E.,Whitehouse, A.J.,Brown, K.,Burbaud, S.,Belardinelli, J.M.,Sangen, J.,Lahiri, R.,Libardo, M.D.J.,Gupta, P.,Malhotra, S.,Boshoff, H.I.M.,Jackson, M.,Abell, C.,Coyne, A.G.,Blundell, T.L.,Floto, R.A.,Mendes, V. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Res., 48:8099-8112, 2020 Cited by PubMed: 32602532DOI: 10.1093/nar/gkaa539 PDB entries with the same primary citation |
Experimental method |
Structure validation
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