6QOQ

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 20 (6-Aminobenzothiazole)

Summary for 6QOQ

• Entry DOI: 10.2210/pdb6qoq/pdb
• Related: 6NVR
• Descriptor: tRNA (guanine-N(1)-)-methyltransferase, 1,3-benzothiazol-6-amine (3 entities in total)
• Functional Keywords: trmd, trna methyltransferase, spout methyltransferase, transferase
• Biological source: Mycobacterium abscessus
• Total number of polymer chains: 2
• Total formula weight: 53169.74

Authors

Thomas, S.E.,Whitehouse, A.J.,Coyne, A.G.,Abell, C.,Mendes, V.,Blundell, T.L. (deposition date: 2019-02-12, release date: 2020-02-26, Last modification date: 2024-05-15)

• Primary citation: Thomas, S.E.,Whitehouse, A.J.,Brown, K.,Burbaud, S.,Belardinelli, J.M.,Sangen, J.,Lahiri, R.,Libardo, M.D.J.,Gupta, P.,Malhotra, S.,Boshoff, H.I.M.,Jackson, M.,Abell, C.,Coyne, A.G.,Blundell, T.L.,Floto, R.A.,Mendes, V.; Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.; Nucleic Acids Res., 48:8099-8112, 2020; PubMed: 32602532; DOI: 10.1093/nar/gkaa539

Experimental method

X-RAY DIFFRACTION (1.67 Å)