6QNS

Crystal structure of the binding domain of Botulinum Neurotoxin type B mutant I1248W/V1249W in complex with human synaptotagmin 1 and GD1a receptors

Summary for 6QNS

Entry DOI	10.2210/pdb6qns/pdb
Descriptor	Botulinum neurotoxin type B, Synaptotagmin-1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	botulinum toxin, toxin
Biological source	Clostridium botulinum More
Total number of polymer chains	2
Total formula weight	56948.79
Authors	Masuyer, G.,Yin, L.,Zhang, S.,Miyashita, S.I.,Dong, M.,Stenmark, P. (deposition date: 2019-02-12, release date: 2020-02-26, Last modification date: 2024-01-24)
Primary citation	Yin, L.,Masuyer, G.,Zhang, S.,Zhang, J.,Miyashita, S.I.,Burgin, D.,Lovelock, L.,Coker, S.F.,Fu, T.M.,Stenmark, P.,Dong, M. Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. Plos Biol., 18:e3000618-e3000618, 2020 Cited by PubMed: 32182233 DOI: 10.1371/journal.pbio.3000618 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation