6QNS

Crystal structure of the binding domain of Botulinum Neurotoxin type B mutant I1248W/V1249W in complex with human synaptotagmin 1 and GD1a receptors

6QNS の概要

• エントリーDOI: 10.2210/pdb6qns/pdb
• 分子名称: Botulinum neurotoxin type B, Synaptotagmin-1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: botulinum toxin, toxin
• 由来する生物種: Clostridium botulinum; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56948.79

構造登録者

Masuyer, G.,Yin, L.,Zhang, S.,Miyashita, S.I.,Dong, M.,Stenmark, P. (登録日: 2019-02-12, 公開日: 2020-02-26, 最終更新日: 2024-01-24)

• 主引用文献: Yin, L.,Masuyer, G.,Zhang, S.,Zhang, J.,Miyashita, S.I.,Burgin, D.,Lovelock, L.,Coker, S.F.,Fu, T.M.,Stenmark, P.,Dong, M.; Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.; Plos Biol., 18:e3000618-e3000618, 2020; PubMed: 32182233; DOI: 10.1371/journal.pbio.3000618

実験手法

X-RAY DIFFRACTION (2.4 Å)