6QNA

Structure of bovine anti-RSV hybrid Fab B13HC-B4LC

Summary for 6QNA

• Entry DOI: 10.2210/pdb6qna/pdb
• Related: 6QN7 6QN8 6QN9
• Descriptor: B13 Heavy chain, B4 light chain, GLYCEROL, ... (4 entities in total)
• Functional Keywords: cattle antibodies, bovine respiratory syncytial virus, anti-rsv b4, anti-rsv b13, hybrid fab, immune system
• Biological source: Bos taurus; More
• Total number of polymer chains: 8
• Total formula weight: 194147.91

Authors

Ren, J.,Nettleship, J.E.,Harris, G.,Mwangi, W.,Rhaman, N.,Grant, C.,Kotecha, A.,Fry, E.,Charleston, B.,Stuart, D.I.,Hammond, J.,Owens, R.J. (deposition date: 2019-02-10, release date: 2019-05-29, Last modification date: 2024-01-24)

• Primary citation: Ren, J.,Nettleship, J.E.,Harris, G.,Mwangi, W.,Rhaman, N.,Grant, C.,Kotecha, A.,Fry, E.,Charleston, B.,Stuart, D.I.,Hammond, J.,Owens, R.J.; The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.; Mol.Immunol., 112:123-130, 2019; PubMed: 31100550; DOI: 10.1016/j.molimm.2019.04.026

Experimental method

X-RAY DIFFRACTION (2.62 Å)