6QMD
Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction
6QMD の概要
エントリーDOI | 10.2210/pdb6qmd/pdb |
分子名称 | Kelch-like ECH-associated protein 1, DIMETHYL SULFOXIDE, (3~{R})-3-(4-chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acid, ... (4 entities in total) |
機能のキーワード | protein ubiquitination, oxidative stress, kelch motif, protein binding |
由来する生物種 | Mus musculus (House mouse) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 35961.01 |
構造登録者 | |
主引用文献 | Heightman, T.D.,Callahan, J.F.,Chiarparin, E.,Coyle, J.E.,Griffiths-Jones, C.,Lakdawala, A.S.,McMenamin, R.,Mortenson, P.N.,Norton, D.,Peakman, T.M.,Rich, S.J.,Richardson, C.,Rumsey, W.L.,Sanchez, Y.,Saxty, G.,Willems, H.M.G.,Wolfe 3rd, L.,Woolford, A.J.,Wu, Z.,Yan, H.,Kerns, J.K.,Davies, T.G. Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. J.Med.Chem., 62:4683-4702, 2019 Cited by PubMed: 30973731DOI: 10.1021/acs.jmedchem.9b00279 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.94 Å) |
構造検証レポート
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