6QHL

14-3-3 sigma with RelA/p65 binding site pS45

Summary for 6QHL

Entry DOI	10.2210/pdb6qhl/pdb
Descriptor	14-3-3 protein sigma, Transcription factor p65, GLYCEROL, ... (4 entities in total)
Functional Keywords	14-3-3, p65, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	29878.21
Authors	Wolter, M.,Ottmann, C. (deposition date: 2019-01-16, release date: 2020-05-13, Last modification date: 2020-12-30)
Primary citation	Wolter, M.,de Vink, P.,Neves, J.F.,Srdanovic, S.,Higuchi, Y.,Kato, N.,Wilson, A.,Landrieu, I.,Brunsveld, L.,Ottmann, C. Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142:11772-11783, 2020 Cited by PubMed: 32501683 DOI: 10.1021/jacs.0c02151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation