6QH9
Crystal Structure of Human Kallikrein 6 in complex with GSK3239861A
Summary for 6QH9
Entry DOI | 10.2210/pdb6qh9/pdb |
Descriptor | Kallikrein-6, UNKNOWN ATOM OR ION, (3~{S})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide, ... (6 entities in total) |
Functional Keywords | protease, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 49968.65 |
Authors | Thorpe, J.H. (deposition date: 2019-01-16, release date: 2019-02-06, Last modification date: 2019-02-27) |
Primary citation | White, G.V.,Edgar, E.V.,Holmes, D.S.,Lewell, X.Q.,Liddle, J.,Polyakova, O.,Smith, K.J.,Thorpe, J.H.,Walker, A.L.,Wang, Y.,Young, R.J.,Hovnanian, A. Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome. Bioorg. Med. Chem. Lett., 29:821-825, 2019 Cited by PubMed: 30691925DOI: 10.1016/j.bmcl.2019.01.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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