6QH9

Crystal Structure of Human Kallikrein 6 in complex with GSK3239861A

6QH9 の概要

• エントリーDOI: 10.2210/pdb6qh9/pdb
• 分子名称: Kallikrein-6, UNKNOWN ATOM OR ION, (3~{S})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide, ... (6 entities in total)
• 機能のキーワード: protease, inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49968.65

構造登録者

Thorpe, J.H. (登録日: 2019-01-16, 公開日: 2019-02-06, 最終更新日: 2019-02-27)

• 主引用文献: White, G.V.,Edgar, E.V.,Holmes, D.S.,Lewell, X.Q.,Liddle, J.,Polyakova, O.,Smith, K.J.,Thorpe, J.H.,Walker, A.L.,Wang, Y.,Young, R.J.,Hovnanian, A.; Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.; Bioorg. Med. Chem. Lett., 29:821-825, 2019; PubMed: 30691925; DOI: 10.1016/j.bmcl.2019.01.020

実験手法

X-RAY DIFFRACTION (2.27 Å)