6QGV

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)

6QGV の概要

• エントリーDOI: 10.2210/pdb6qgv/pdb
• 分子名称: Egl nine homolog 1, MANGANESE (II) ION, 8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26940.42

構造登録者

Chowdhury, R.,Holt-Martyn, J.P.,Rahman, M.Z.,Schofield, C.J. (登録日: 2019-01-13, 公開日: 2020-02-05, 最終更新日: 2024-01-24)

• 主引用文献: Holt-Martyn, J.P.,Tumber, A.,Rahman, M.Z.,Lippl, K.,Figg Jr., W.,McDonough, M.A.,Chowdhury, R.,Schofield, C.J.; Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors.; Medchemcomm, 10:500-504, 2019; PubMed: 31057728; DOI: 10.1039/c8md00548f

実験手法

X-RAY DIFFRACTION (1.4 Å)