6QG4

Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine inhibitor 1h

6QG4 の概要

• エントリーDOI: 10.2210/pdb6qg4/pdb
• 関連するPDBエントリー: 6QFL 6QFR 6QFT
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 7, 1-[(3~{R})-3-[4-azanyl-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one (3 entities in total)
• 機能のキーワード: protein kinase, kinase, mkk7, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36513.28

構造登録者

Wolle, P.,Mueller, M.P.,Rauh, D. (登録日: 2019-01-10, 公開日: 2019-05-22, 最終更新日: 2024-01-24)

• 主引用文献: Wolle, P.,Engel, J.,Smith, S.,Goebel, L.,Hennes, E.,Lategahn, J.,Rauh, D.; Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).; J.Med.Chem., 62:5541-5546, 2019; PubMed: 31083997; DOI: 10.1021/acs.jmedchem.9b00472

実験手法

X-RAY DIFFRACTION (2.3 Å)