6QFW

Human carbonic anhydrase II with bound IrCp* complex (cofactor 9) to generate an artificial transfer hydrogenase (ATHase)

Summary for 6QFW

• Entry DOI: 10.2210/pdb6qfw/pdb
• Descriptor: Carbonic anhydrase 2, 4-[3-(8-chloranyl-2',3',4',5',6'-pentamethyl-4-oxidanyl-7-oxidanylidene-spiro[1$l^{4},8$l^{4}-diaza-9$l^{7}-iridabicyclo[4.3.0]nona-1,3,5-triene-9,1'-1$l^{7}-iridapentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-8-yl)propyl]benzenesulfonamide, ZINC ION, ... (6 entities in total)
• Functional Keywords: artificial transfer hydrogenase, bound ircp* complex, zinc binding protein, human carbonic anhydrase ii, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30324.02

Authors

Rebelein, J.G. (deposition date: 2019-01-10, release date: 2019-04-17, Last modification date: 2024-01-24)

• Primary citation: Rebelein, J.G.,Cotelle, Y.,Garabedian, B.,Ward, T.R.; Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein.; Acs Catalysis, 9:4173-4178, 2019; PubMed: 31080690; DOI: 10.1021/acscatal.9b01006

Experimental method

X-RAY DIFFRACTION (1.2 Å)