6QFQ

Structure of human Mcl-1 in complex with indole acid inhibitor

6QFQ の概要

• エントリーDOI: 10.2210/pdb6qfq/pdb
• 関連するPDBエントリー: 6qfi 6qfm
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, 7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid (3 entities in total)
• 機能のキーワード: apoptosis, mcl1, bcl2, small molecule inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20372.17

構造登録者

Dokurno, P.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Graham, C.J.,Harris, R.,Jordan, A.M.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. (登録日: 2019-01-10, 公開日: 2019-06-12, 最終更新日: 2024-01-24)

• 主引用文献: Murray, J.B.,Davidson, J.,Chen, I.,Davis, B.,Dokurno, P.,Graham, C.J.,Harris, R.,Jordan, A.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.D.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E.; Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.; Acs Omega, 4:8892-8906, 2019; PubMed: 31459977; DOI: 10.1021/acsomega.9b00611

実験手法

X-RAY DIFFRACTION (1.6 Å)