6QFL

Structure of the mitogen activated kinase kinase 7 active conformation

Summary for 6QFL

DescriptorDual specificity mitogen-activated protein kinase kinase 7 (2 entities in total)
Functional Keywordsprotein kinase, kinase, mkk7, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight36146.86
Authors
Wolle, P.,Mueller, M.P.,Rauh, D. (deposition date: 2019-01-10, release date: 2019-05-22, Last modification date: 2019-06-12)
Primary citation
Wolle, P.,Engel, J.,Smith, S.,Goebel, L.,Hennes, E.,Lategahn, J.,Rauh, D.
Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
J.Med.Chem., 2019
PubMed: 31083997 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.9b00472
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.247300 2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6qfl
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Molmil generated image of 6qfl
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Molmil generated image of 6qfl
rotated about y axis by 90°