6QEG

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR 2-Oxo-1-phenyl-pyrrolidine-3-carboxylic acid (2-thiophen-2-yl-ethyl)-amide

6QEG の概要

• エントリーDOI: 10.2210/pdb6qeg/pdb
• 分子名称: Methionine aminopeptidase 2, GLYCEROL, (3~{S})-3-oxidanyl-2-oxidanylidene-1-phenyl-~{N}-(2-thiophen-2-ylethyl)pyrrolidine-3-carboxamide, ... (5 entities in total)
• 機能のキーワード: hydrolase, peptidase, metal ion binding, proteolysis, hydrolase-hydrolase inhibitor complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43002.58

構造登録者

Musil, D.,Heinrich, T.,Lehmann, M. (登録日: 2019-01-07, 公開日: 2019-05-01, 最終更新日: 2024-05-15)

• 主引用文献: Heinrich, T.,Seenisamy, J.,Blume, B.,Bomke, J.,Calderini, M.,Eckert, U.,Friese-Hamim, M.,Kohl, R.,Lehmann, M.,Leuthner, B.,Musil, D.,Rohdich, F.,Zenke, F.T.; Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.; J.Med.Chem., 62:5025-5039, 2019; PubMed: 30939017; DOI: 10.1021/acs.jmedchem.9b00041

実験手法

X-RAY DIFFRACTION (2.08 Å)