6QDU
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC
Summary for 6QDU
Entry DOI | 10.2210/pdb6qdu/pdb |
Descriptor | 14-3-3 protein sigma, FC-NCPC, PHOSPHOTHREONINE, ... (6 entities in total) |
Functional Keywords | neuron regeneration, ppi, phosphorylation, chaperone |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27487.28 |
Authors | Andrei, S.A.,Kaplan, A.,Fournier, A.E.,Ottman, C. (deposition date: 2019-01-02, release date: 2020-01-29, Last modification date: 2024-01-24) |
Primary citation | Kaplan, A.,Andrei, S.A.,van Regteren Altena, A.,Simas, T.,Banerjee, S.L.,Kato, N.,Bisson, N.,Higuchi, Y.,Ottmann, C.,Fournier, A.E. Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27:657-667.e6, 2020 Cited by PubMed: 32220335DOI: 10.1016/j.chembiol.2020.02.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.632 Å) |
Structure validation
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