6QBU

Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC188

6QBU の概要

• エントリーDOI: 10.2210/pdb6qbu/pdb
• 分子名称: Chymotrypsin-like elastase family member 1, ~{N}-[[1-[(4-chlorophenyl)methyl]-1,2,3-triazol-4-yl]methyl]-2-hydrosulfonyl-2-methyl-propanamide, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: serine hydrolases, pancreatic porcine elastase, inhibitor, 3-oxo-beta-sultams, sulfonylation, hydrolase
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26616.95

構造登録者

Brito, J.A.,Almeida, V.T.,Carvalho, L.M.,Moreira, R.,Archer, M. (登録日: 2018-12-21, 公開日: 2020-04-08, 最終更新日: 2024-01-24)

• 主引用文献: Carvalho, L.A.R.,Almeida, V.T.,Brito, J.A.,Lum, K.M.,Oliveira, T.F.,Guedes, R.C.,Goncalves, L.M.,Lucas, S.D.,Cravatt, B.F.,Archer, M.,Moreira, R.; 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling.; Acs Chem.Biol., 15:878-883, 2020; PubMed: 32176480; DOI: 10.1021/acschembio.0c00090

実験手法

X-RAY DIFFRACTION (1.38 Å)