ERK2 mini-fragment binding

Summary for 6QAH

DescriptorMitogen-activated protein kinase 1, SULFATE ION, 1-azanylpropylideneazanium, ... (4 entities in total)
Functional Keywordsser/thr kinase, signal transduction, atp binding, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight42794.22
O'Reilly, M.,Cleasby, A.,Davies, T.G.,Hall, R.,Ludlow, F.,Murray, C.W.,Tisi, D.,Jhoti, H. (deposition date: 2018-12-19, release date: 2019-06-26)
Primary citation
O'Reilly, M.,Cleasby, A.,Davies, T.G.,Hall, R.J.,Ludlow, R.F.,Murray, C.W.,Tisi, D.,Jhoti, H.
Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design.
Drug Discov Today, 24:1081-1086, 2019
PubMed: 30878562 (PDB entries with the same primary citation)
DOI: 10.1016/j.drudis.2019.03.009
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2222 0.3% 0.3% 11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report