6QAD

Human Butyrylcholinesterase in complex with ((S)-2-(butylamino)-N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-3-(1H-indol-3-yl)propanamide

Summary for 6QAD

Entry DOI	10.2210/pdb6qad/pdb
Descriptor	Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	butyrylcholinesterase, inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	66640.33
Authors	Brazzolotto, X.,Nachon, F.,Harst, M.,Knez, D.,Gobec, S. (deposition date: 2018-12-19, release date: 2019-03-27, Last modification date: 2024-01-24)
Primary citation	Meden, A.,Knez, D.,Jukic, M.,Brazzolotto, X.,Grsic, M.,Pislar, A.,Zahirovic, A.,Kos, J.,Nachon, F.,Svete, J.,Gobec, S.,Groselj, U. Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease. Chem.Commun.(Camb.), 55:3765-3768, 2019 Cited by PubMed: 30864579 DOI: 10.1039/c9cc01330j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.497 Å)

Structure validation