6Q9H
HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 11 AT 2.0A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Summary for 6Q9H
Entry DOI | 10.2210/pdb6q9h/pdb |
Related | 50C8 6Q96 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (4~{S})-5-(3-chloranyl-2-fluoranyl-phenyl)-4-(4-chloranyl-2-methyl-phenyl)-3-propan-2-yl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one (3 entities in total) |
Functional Keywords | ppi with p53, inhibitor complex, cell cycle, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 11574.34 |
Authors | Kallen, J. (deposition date: 2018-12-18, release date: 2019-05-15, Last modification date: 2024-01-24) |
Primary citation | Kallen, J.,Izaac, A.,Chau, S.,Wirth, E.,Schoepfer, J.,Mah, R.,Schlapbach, A.,Stutz, S.,Vaupel, A.,Guagnano, V.,Masuya, K.,Stachyra, T.M.,Salem, B.,Chene, P.,Gessier, F.,Holzer, P.,Furet, P. Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14:1305-1314, 2019 Cited by PubMed: 31066983DOI: 10.1002/cmdc.201900201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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