6Q9H

HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 11 AT 2.0A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

6Q9H の概要

• エントリーDOI: 10.2210/pdb6q9h/pdb
• 関連するPDBエントリー: 50C8 6Q96
• 分子名称: E3 ubiquitin-protein ligase Mdm2, (4~{S})-5-(3-chloranyl-2-fluoranyl-phenyl)-4-(4-chloranyl-2-methyl-phenyl)-3-propan-2-yl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one (3 entities in total)
• 機能のキーワード: ppi with p53, inhibitor complex, cell cycle, ligase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11574.34

構造登録者

Kallen, J. (登録日: 2018-12-18, 公開日: 2019-05-15, 最終更新日: 2024-01-24)

• 主引用文献: Kallen, J.,Izaac, A.,Chau, S.,Wirth, E.,Schoepfer, J.,Mah, R.,Schlapbach, A.,Stutz, S.,Vaupel, A.,Guagnano, V.,Masuya, K.,Stachyra, T.M.,Salem, B.,Chene, P.,Gessier, F.,Holzer, P.,Furet, P.; Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.; Chemmedchem, 14:1305-1314, 2019; PubMed: 31066983; DOI: 10.1002/cmdc.201900201

実験手法

X-RAY DIFFRACTION (2 Å)