6Q92
Crystal structure of human Arginase-1 at pH 7.0 in complex with ABH
Summary for 6Q92
Entry DOI | 10.2210/pdb6q92/pdb |
Descriptor | Arginase-1, MANGANESE (II) ION, 2(S)-AMINO-6-BORONOHEXANOIC ACID, ... (5 entities in total) |
Functional Keywords | hydrolase inhibitor, borate, manganese cluster, ph-dependent, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 74552.18 |
Authors | Grobben, Y.,Uitdehaag, J.C.M.,Zaman, G.J.R. (deposition date: 2018-12-17, release date: 2019-12-11, Last modification date: 2024-01-24) |
Primary citation | Grobben, Y.,Uitdehaag, J.C.M.,Willemsen-Seegers, N.,Tabak, W.W.A.,de Man, J.,Buijsman, R.C.,Zaman, G.J.R. Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158. J Struct Biol X, 4:100014-100014, 2020 Cited by PubMed: 32647818DOI: 10.1016/j.yjsbx.2019.100014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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