6Q8K

CLK1 with bound pyridoquinazoline

6Q8K の概要

• エントリーDOI: 10.2210/pdb6q8k/pdb
• 分子名称: Dual specificity protein kinase CLK1, 1,2-ETHANEDIOL, ~{N}2-(3-morpholin-4-ylpropyl)pyrido[3,4-g]quinazoline-2,10-diamine, ... (4 entities in total)
• 機能のキーワード: clk1, dual specifity protein kinase clk1, inhibitor, kinase, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39981.99

構造登録者

Schroeder, M.,Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.,Khiari, J.,Joesselin, B.,Bach, S.,Ruchaud, S.,Anizon, F.,Giraud, F.,Moreau, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2018-12-14, 公開日: 2019-02-20, 最終更新日: 2019-02-27)

• 主引用文献: Tazarki, H.,Zeinyeh, W.,Esvan, Y.J.,Knapp, S.,Chatterjee, D.,Schroder, M.,Joerger, A.C.,Khiari, J.,Josselin, B.,Baratte, B.,Bach, S.,Ruchaud, S.,Anizon, F.,Giraud, F.,Moreau, P.; New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.; Eur J Med Chem, 166:304-317, 2019; PubMed: 30731399; DOI: 10.1016/j.ejmech.2019.01.052

実験手法

X-RAY DIFFRACTION (2.29 Å)