6Q8F

Nterminal domain of human SMU1

Summary for 6Q8F

DescriptorWD40 repeat-containing protein SMU1, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... (4 entities in total)
Functional Keywordssplicing factor, splicing
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight115592.29
Authors
Primary citation
Ashraf, U.,Tengo, L.,Le Corre, L.,Fournier, G.,Busca, P.,McCarthy, A.A.,Rameix-Welti, M.A.,Gravier-Pelletier, C.,Ruigrok, R.W.H.,Jacob, Y.,Vidalain, P.O.,Pietrancosta, N.,Crepin, T.,Naffakh, N.
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116:10968-10977, 2019
PubMed: 31076555 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1901214116
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.221100 2.7% 4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6q8f
no rotation
Molmil generated image of 6q8f
rotated about x axis by 90°
Molmil generated image of 6q8f
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6q8f
no rotation
Molmil generated image of 6q8f
rotated about x axis by 90°
Molmil generated image of 6q8f
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6q8f.pdb1.gz [67.18 KB])