6Q74

PI3K delta in complex with 1benzylN[5(3,6dihydro2Hpyran4yl)2methoxypyridin3yl]2methyl1Himidazole4sulfonamide

6Q74 の概要

• エントリーDOI: 10.2210/pdb6q74/pdb
• 関連するPDBエントリー: 6Q6Y 6Q73
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[5-(3,6-dihydro-2~{H}-pyran-4-yl)-2-methoxy-pyridin-3-yl]-2-methyl-1-(phenylmethyl)imidazole-4-sulfonamide (3 entities in total)
• 機能のキーワード: pi3 kinase delta, complex, structure based design, transferase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108264.18

構造登録者

Convery, M.A.,Rowland, P.,Down, K.,Barton, N. (登録日: 2018-12-12, 公開日: 2018-12-26, 最終更新日: 2024-06-19)

• 主引用文献: Barton, N.,Convery, M.,Cooper, A.W.J.,Down, K.,Hamblin, J.N.,Inglis, G.,Peace, S.,Rowedder, J.,Rowland, P.,Taylor, J.A.,Wellaway, N.; Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase delta through a Deconstruction and Regrowth Approach.; J.Med.Chem., 61:11061-11073, 2018; PubMed: 30532965; DOI: 10.1021/acs.jmedchem.8b01556

実験手法

X-RAY DIFFRACTION (2.48 Å)