6Q6H

Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class

Summary for 6Q6H

• Entry DOI: 10.2210/pdb6q6h/pdb
• EMDB information: 4463 4464 4465 4466 4467
• Descriptor: Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 13, Anaphase-promoting complex subunit 16, ... (16 entities in total)
• Functional Keywords: spindle assembly checkpoint, anaphase-promoting complex, cyclin, ubiquitination, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 21
• Total formula weight: 1262162.38

Authors

Zhang, S.,Barford, D. (deposition date: 2018-12-11, release date: 2019-09-11)

• Primary citation: Zhang, S.,Tischer, T.,Barford, D.; Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.; Nat Commun, 10:3863-3863, 2019; PubMed: 31455778; DOI: 10.1038/s41467-019-11833-2

Experimental method

ELECTRON MICROSCOPY (3.2 Å)