6Q50

Structure of MPT-4, a mannose phosphorylase from Leishmania mexicana, in complex with phosphate ion

Summary for 6Q50

Entry DOI	10.2210/pdb6q50/pdb
Related	2B4W
Descriptor	MPT-4, PHOSPHATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	phosphorylase, hydrolase
Biological source	Leishmania mexicana (strain MHOM/GT/2001/U1103)
Total number of polymer chains	1
Total formula weight	37781.47
Authors	Sobala, L.F.,Males, A.,Bastidas, L.M.,Ward, T.,Sernee, M.F.,Ralton, J.E.,Nero, T.L.,Cobbold, S.,Kloehn, J.,Viera-Lara, M.,Stanton, L.,Hanssen, E.,Parker, M.W.,Williams, S.J.,McConville, M.J.,Davies, G.J. (deposition date: 2018-12-06, release date: 2019-09-25, Last modification date: 2024-01-24)
Primary citation	Sernee, M.F.,Ralton, J.E.,Nero, T.L.,Sobala, L.F.,Kloehn, J.,Vieira-Lara, M.A.,Cobbold, S.A.,Stanton, L.,Pires, D.E.V.,Hanssen, E.,Males, A.,Ward, T.,Bastidas, L.M.,van der Peet, P.L.,Parker, M.W.,Ascher, D.B.,Williams, S.J.,Davies, G.J.,McConville, M.J. A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites. Cell Host Microbe, 26:385-399.e9, 2019 Cited by PubMed: 31513773 DOI: 10.1016/j.chom.2019.08.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation