6Q4Z

Structure of an inactive variant (D94N) of MPT-2, a GDP-Man-dependent mannosyltransferase from Leishmania mexicana, in complex with beta-1,2-mannobiose

Summary for 6Q4Z

Entry DOI	10.2210/pdb6q4z/pdb
Descriptor	LmxM MPT-2 D94N, beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose (3 entities in total)
Functional Keywords	transferase
Biological source	Leishmania mexicana MHOM/GT/2001/U1103
Total number of polymer chains	2
Total formula weight	76869.12
Authors	Sobala, L.F.,Males, A.,Bastidas, L.M.,Ward, T.,Sernee, M.F.,Ralton, J.E.,Nero, T.L.,Kloehn, J.,Viera-Lara, M.,Stanton, L.,Cobbold, S.,Pires, D.E.,Hanssen, E.,Parker, M.W.,Ascher, D.B.,Williams, S.J.,McConville, M.J.,Davies, G.J. (deposition date: 2018-12-06, release date: 2019-09-25, Last modification date: 2024-01-24)
Primary citation	Sernee, M.F.,Ralton, J.E.,Nero, T.L.,Sobala, L.F.,Kloehn, J.,Vieira-Lara, M.A.,Cobbold, S.A.,Stanton, L.,Pires, D.E.V.,Hanssen, E.,Males, A.,Ward, T.,Bastidas, L.M.,van der Peet, P.L.,Parker, M.W.,Ascher, D.B.,Williams, S.J.,Davies, G.J.,McConville, M.J. A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites. Cell Host Microbe, 26:385-399.e9, 2019 Cited by PubMed: 31513773 DOI: 10.1016/j.chom.2019.08.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation