6Q4Z

Structure of an inactive variant (D94N) of MPT-2, a GDP-Man-dependent mannosyltransferase from Leishmania mexicana, in complex with beta-1,2-mannobiose

6Q4Z の概要

• エントリーDOI: 10.2210/pdb6q4z/pdb
• 分子名称: LmxM MPT-2 D94N, beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Leishmania mexicana MHOM/GT/2001/U1103
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76869.12

構造登録者

Sobala, L.F.,Males, A.,Bastidas, L.M.,Ward, T.,Sernee, M.F.,Ralton, J.E.,Nero, T.L.,Kloehn, J.,Viera-Lara, M.,Stanton, L.,Cobbold, S.,Pires, D.E.,Hanssen, E.,Parker, M.W.,Ascher, D.B.,Williams, S.J.,McConville, M.J.,Davies, G.J. (登録日: 2018-12-06, 公開日: 2019-09-25, 最終更新日: 2024-01-24)

• 主引用文献: Sernee, M.F.,Ralton, J.E.,Nero, T.L.,Sobala, L.F.,Kloehn, J.,Vieira-Lara, M.A.,Cobbold, S.A.,Stanton, L.,Pires, D.E.V.,Hanssen, E.,Males, A.,Ward, T.,Bastidas, L.M.,van der Peet, P.L.,Parker, M.W.,Ascher, D.B.,Williams, S.J.,Davies, G.J.,McConville, M.J.; A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.; Cell Host Microbe, 26:385-399.e9, 2019; PubMed: 31513773; DOI: 10.1016/j.chom.2019.08.009

実験手法

X-RAY DIFFRACTION (1.55 Å)