6Q3Z
Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k
6Q3Z の概要
エントリーDOI | 10.2210/pdb6q3z/pdb |
分子名称 | Bromodomain-containing protein 4, (7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-[(4-methylthiophen-2-yl)methyl]-7~{H}-pteridin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
機能のキーワード | brd4(bd1), inhibitor, complex, structural genomics, structural genomics consortium, sgc, gene regulation |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 31702.67 |
構造登録者 | Heidenreich, D.,Watts, E.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Knapp, S.,Hoelder, S.,Structural Genomics Consortium (SGC) (登録日: 2018-12-04, 公開日: 2019-03-06, 最終更新日: 2024-01-24) |
主引用文献 | Watts, E.,Heidenreich, D.,Tucker, E.,Raab, M.,Strebhardt, K.,Chesler, L.,Knapp, S.,Bellenie, B.,Hoelder, S. Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity. J.Med.Chem., 62:2618-2637, 2019 Cited by PubMed: 30789735DOI: 10.1021/acs.jmedchem.8b01947 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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