6Q2A

Trypanosoma brucei CLK1 kinase domain in complex with a covalent aminobenzimidazole inhibitor AB1

6Q2A の概要

• エントリーDOI: 10.2210/pdb6q2a/pdb
• 分子名称: Protein kinase, putative, SULFATE ION, ~{N}-[1-[(3~{R})-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-benzimidazol-2-yl]-2-methyl-pyridine-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 668678.53

構造登録者

Ma, X.,Ornelas, E. (登録日: 2019-08-07, 公開日: 2020-06-17, 最終更新日: 2023-10-11)

• 主引用文献: Saldivia, M.,Fang, E.,Ma, X.,Myburgh, E.,Carnielli, J.B.T.,Bower-Lepts, C.,Brown, E.,Ritchie, R.,Lakshminarayana, S.B.,Chen, Y.L.,Patra, D.,Ornelas, E.,Koh, H.X.Y.,Williams, S.L.,Supek, F.,Paape, D.,McCulloch, R.,Kaiser, M.,Barrett, M.P.,Jiricek, J.,Diagana, T.T.,Mottram, J.C.,Rao, S.P.S.; Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.; Nat Microbiol, 5:1207-1216, 2020; PubMed: 32661312; DOI: 10.1038/s41564-020-0745-6

実験手法

X-RAY DIFFRACTION (2.6 Å)