6Q23

Crystal structure of human 1G01 Fab in complex with influenza virus neuraminidase from A/California/04/2009 (H1N1)

Summary for 6Q23

• Entry DOI: 10.2210/pdb6q23/pdb
• Descriptor: Neuraminidase, 1G01 Fab IgG1 heavy chain, 1G01 Fab kappa light chain, ... (5 entities in total)
• Functional Keywords: broadly protective human antibody, inhibition, active site, antibody-neuraminidase complex, viral protein, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Influenza A virus (A/California/04/2009 (H1N1); More
• Total number of polymer chains: 12
• Total formula weight: 372639.03

Authors

Zhu, X.,Wilson, I.A. (deposition date: 2019-08-06, release date: 2019-10-23, Last modification date: 2023-10-11)

• Primary citation: Stadlbauer, D.,Zhu, X.,McMahon, M.,Turner, J.S.,Wohlbold, T.J.,Schmitz, A.J.,Strohmeier, S.,Yu, W.,Nachbagauer, R.,Mudd, P.A.,Wilson, I.A.,Ellebedy, A.H.,Krammer, F.; Broadly protective human antibodies that target the active site of influenza virus neuraminidase.; Science, 366:499-504, 2019; PubMed: 31649200; DOI: 10.1126/science.aay0678

Experimental method

X-RAY DIFFRACTION (3.27 Å)