6PZ1

Crystal Structure of human Indoleamine 2,3-Dioxygenase 1 in complex with PF-06840003 in Active Site and Si site

Summary for 6PZ1

Entry DOI	10.2210/pdb6pz1/pdb
Related	6PYY 6PYZ
Descriptor	Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, ... (5 entities in total)
Functional Keywords	indoamine 2, 3-dioxygenase, pf-06840003, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	97973.91
Authors	Pham, K.N.,Lewis-Ballester, A.,Yeh, S.R. (deposition date: 2019-07-31, release date: 2020-01-01, Last modification date: 2023-10-11)
Primary citation	Pham, K.N.,Lewis-Ballester, A.,Yeh, S.R. Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase. J.Am.Chem.Soc., 141:18771-18779, 2019 Cited by PubMed: 31682426 DOI: 10.1021/jacs.9b08871 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation