6PYR

Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one)

6PYR の概要

• エントリーDOI: 10.2210/pdb6pyr/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one, ... (4 entities in total)
• 機能のキーワード: pi3kdelta kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 137926.69

構造登録者

Lesburg, C.A.,Augustin, M.A. (登録日: 2019-07-30, 公開日: 2019-08-28, 最終更新日: 2024-03-13)

• 主引用文献: Fradera, X.,Methot, J.L.,Achab, A.,Christopher, M.,Altman, M.D.,Zhou, H.,McGowan, M.A.,Kattar, S.D.,Wilson, K.,Garcia, Y.,Augustin, M.A.,Lesburg, C.A.,Shah, S.,Goldenblatt, P.,Katz, J.D.; Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow.; Bioorg.Med.Chem.Lett., 29:2575-2580, 2019; PubMed: 31416665; DOI: 10.1016/j.bmcl.2019.08.004

実験手法

X-RAY DIFFRACTION (2.21 Å)