6PYE

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with NR160

Summary for 6PYE

Entry DOI	10.2210/pdb6pye/pdb
Descriptor	Hdac6 protein, N-[(1-benzyl-1H-tetrazol-5-yl)methyl]-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-2-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	histone deacetylase, metallohydrolase, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	2
Total formula weight	82313.59
Authors	Osko, J.D.,Christianson, D.W. (deposition date: 2019-07-29, release date: 2020-07-29, Last modification date: 2023-10-11)
Primary citation	Ressing, N.,Sonnichsen, M.,Osko, J.D.,Scholer, A.,Schliehe-Diecks, J.,Skerhut, A.,Borkhardt, A.,Hauer, J.,Kassack, M.U.,Christianson, D.W.,Bhatia, S.,Hansen, F.K. Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J.Med.Chem., 63:10339-10351, 2020 Cited by PubMed: 32803970 DOI: 10.1021/acs.jmedchem.9b01888 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48000295888 Å)

Structure validation