6PYE

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with NR160

6PYE の概要

• エントリーDOI: 10.2210/pdb6pye/pdb
• 分子名称: Hdac6 protein, N-[(1-benzyl-1H-tetrazol-5-yl)methyl]-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-2-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: histone deacetylase, metallohydrolase, hydrolase
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82313.59

構造登録者

Osko, J.D.,Christianson, D.W. (登録日: 2019-07-29, 公開日: 2020-07-29, 最終更新日: 2023-10-11)

• 主引用文献: Ressing, N.,Sonnichsen, M.,Osko, J.D.,Scholer, A.,Schliehe-Diecks, J.,Skerhut, A.,Borkhardt, A.,Hauer, J.,Kassack, M.U.,Christianson, D.W.,Bhatia, S.,Hansen, F.K.; Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups.; J.Med.Chem., 63:10339-10351, 2020; PubMed: 32803970; DOI: 10.1021/acs.jmedchem.9b01888

実験手法

X-RAY DIFFRACTION (1.48000295888 Å)